Journal
MOLECULES
Volume 22, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules22030461
Keywords
pyrroles; pyrrolopyridines; synthesis; anti-inflammatory assay; cytokine inhibitors; docking study
Funding
- Pharmaceutical Organic Chemistry
- Faculty of Pharmacy, Helwan University
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A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, H-1-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site.
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