Journal
MOLECULES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules22121999
Keywords
marine-derived fungus; Penicillium sp; SCSIO Ind16F01; xanthone; chromone; N-methyl quinolone lactams
Funding
- National Natural Science Foundation of China [21202080, 41376162]
- Guangdong Natural Science Foundation [2014A030313724, 2014A030313765]
- Open Research Fund Program of Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University [PRRD-2017-ZD3]
- Pearl River S&T Nova Program of Guangzhou Scientific Research Project [201610010017]
- Project of Administration of Traditional Chinese Medicine of Guangdong Province of China [20161166]
- Research Fund Program of Guangdong Key Laboratory of Marine Materia Medica [LMM2016-5]
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Chemical investigation of the fungus Penicillium sp. SCSIO Ind16F01 derived from deep-sea sediment sample afforded a new xanthone, 3,8-dihydroxy-2-methyl-9-oxoxanthene-4-carboxylic acid methyl ester (1) and a new chromone, coniochaetone J (2), together with three known xanthones, 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), 7,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (4), 1,6,8-trihydroxy-3-(hydroxymethyl)anthraquinone (5), three known chromones, coniochaetone B (6), citrinolactones B (7), epiremisporine B (8), and four reported rare class of N-methyl quinolone lactams: quinolactacins B (9), C1 (10), and C2 (11), and quinolonimide (12). The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. Those isolated compounds were evaluated for their antiviral (EV71 and H3N2) and cytotoxic activities.
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