Journal
GENOME BIOLOGY
Volume 20, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13059-018-1612-0
Keywords
Cancer genomics screens; Cancer genes; Cancer heterogeneity; Systems-level properties
Funding
- Cancer Research UK [C43634/A25487]
- Cancer Research UK King's Health Partners Centre at King's College London
- EPSRC Centre for Doctoral Training in Cross-Disciplinary Approaches to Non-Equilibrium Systems (CANES) [EP/L015854/1]
- Health Education England (HEE) Genomics Education Programme (GEP)
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The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. Thisrepresents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/.
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