Journal
MOLECULES
Volume 22, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules22101743
Keywords
antimicrobial; chronic infection; diabetes; peptides; ulcers; wound-healing; skin and soft tissue infections (SSTI)
Funding
- Fundacao para a Ciencia e Tecnologia (FCT, Portugal) [UID/QUI/50006/2013, PD/BD/135073/2017]
- Comissao de Coordenacao e Desenvolvimento Regional do Norte (CCDR-N)/NORTE/Portugal through project DESignBIOtechHealth [Norte-01-0145-FEDER-000024]
- Fundação para a Ciência e a Tecnologia [PD/BD/135073/2017] Funding Source: FCT
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As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections.
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