Journal
JOURNAL OF AGING AND HEALTH
Volume 31, Issue 1, Pages 109-138Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0898264317724549
Keywords
HIV/AIDS; sub-Saharan Africa; aging; gerontology; inflammation; noncommunicable diseases
Categories
Funding
- National Institutes of Health
- Harvard Center for AIDS Research [K23 MH099916, R21 HL124712, P30 AI060354, R24 AG044325]
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Objective: The number of people living with HIV (PLWH) over 50 years old in sub-Saharan Africa is predicted to triple in the coming decades, to 6-10 million. Yet, there is a paucity of data on the determinants of health and quality of life for older PLWH in the region. Methods: A review was undertaken to describe the impact of HIV infection on aging for PLWH in sub-Saharan Africa. Results: We (a) summarize the pathophysiology and epidemiology of aging with HIV in resource-rich settings, and (b) describe how these relationships might differ in sub-Saharan Africa, (c) propose a conceptual framework to describe determinants of quality of life for older PLWH, and (d) suggest priority research areas needed to ensure long-term gains in quality of life for PLWH in the region. Conclusions: Differences in traditional, lifestyle, and envirnomental risk factors, as well as unique features of HIV epidemiology and care delivery appear to substantially alter the contribution of HIV to aging in sub-Saharan Africa. Meanwhile, unique preferences and conceptualizations of quality of life will require novel measurement and intervention tools. An expanded research and public health infrastructure is needed to ensure that gains made in HIV prevention and treamtent are translated into long-term benefits in this region.
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