Journal
PEDIATRIC OBESITY
Volume 14, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/ijpo.12459
Keywords
drug metabolism; CYP2C19; pediatric obesity; pantoprazole
Categories
Funding
- National Institute of Child Health and Human Development [1T32HD069038-05] Funding Source: Medline
- NCATS NIH HHS [L40 TR000598] Funding Source: Medline
- NICHD NIH HHS [T32 HD069038] Funding Source: Medline
- Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology [5T32HD069038-04] Funding Source: Medline
- The Children's Mercy Hospital Funding Source: Medline
- Eunice Kennedy Shriver National Institute of Child Health and Human Development Pediatric Trials Network [NICHD-2012-PAN01] Funding Source: Medline
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Background Children with obesity are more likely to suffer gastroesophageal reflux disease, requiring acid-suppression therapy with proton pump inhibitors (PPIs) and no guidelines regarding dosing. Objective To prospectively evaluate lean-body-weight-based (LBW) dosing of the PPI pantoprazole for children with and without obesity. Methods Methods : Sixty-two children (6-17 years) received a one-time oral dose of liquid pantoprazole (1.2 mg kg(-1) LBW). Plasma pantoprazole concentrations were measured at 10 time points over 8 h and pharmacokinetic (PK) profiles generated using non-compartmental techniques, in order to compare PK parameters of interest between children with and without obesity, while accounting for CYP2C19 genotype. Results Adjusted for milligram-per-kilogram total body weight (TBW) pantoprazole received, apparent drug clearance (CL/F) was reduced 50% in children with vs. without obesity (p=0.03). LBW-based dosing compensated for this reduction in CL/F (p = 0.15). Conclusion To achieve comparable systemic PPI exposures for children with and without obesity, we recommend using LBW, rather than TBW-based dosing for pantoprazole.
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