Journal
MOLECULES
Volume 22, Issue 8, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules22081341
Keywords
Sijunzi Decoction; SJZD; pectic polysaccharide; oxidative stress; antioxidant defense
Funding
- International Cooperation Projects of Science & Technology Department of Sichuan Province [2017HH0093]
- General Financial Grant from the China Postdoctoral Science Foundation [2016M602704]
- National Natural Science Foundation of China [31501200]
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Sijunzi Decoction (SJZD) is a formula used for the treatment of spleen deficiency and gastrointestinal diseases in Traditional Chinese Medicine. Polysaccharides are reported to be the main components of SJZD responsible for its bio-functions. However, highly purified and clearly characterized polysaccharides from SJZD are not well described. Here we obtained a purified polysaccharide (SJZDP-II-I) from SJZD using ion exchange chromatography and gel filtration. Structure analysis by FT-IR and NMR identified SJZDP-II-I as a typical pectic polysaccharide with homogalacturonan and rhamnogalacturonan type I regions and arabinogalactan type I and II as side chains. In vitro studies indicated that SJZDP-II-I treatment could significantly enhance the total antioxidant capacity of SW480 cells, resulting from the promoted expressions of antioxidant enzymes and their master regulator PGC-1 alpha, which would be valuable for further research and applications.
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