4.6 Article

Dichlorotrifluoromethoxyacetic Acid: Preparation and Reactivity

Journal

MOLECULES
Volume 22, Issue 6, Pages -

Publisher

MDPI
DOI: 10.3390/molecules22060966

Keywords

fluorine; trifluoromethoxy; amides

Funding

  1. CNRS
  2. University of Versailles
  3. French Ministry of Research
  4. French Fluorine Network

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We describe the first gram scale preparation of the reagent dichlorotrifluoromethoxyacetic acid. This stable compound is obtained in five steps starting from the cheap diethylene glycol. The reactivity of the sodium salt of this fluorinated acid was also tested and allowed the preparation of new amides.

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