Journal
ELECTROCHIMICA ACTA
Volume 165, Issue -, Pages 116-121Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2015.03.015
Keywords
Electrocatalysis; Mediator; Sodium bromide; 3-(5-Hydroxy-3-methylpyrazol-4-yl)-3-arylpropionitriles; Cyclization; Spirocyclopropylpyrazolones
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Funding
- Russian Academy of Sciences Program [OKh-01]
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Electrolysis of 3-(5-hydroxy-3-methylpyrazol-4-yl)-3-arylpropionitriles in alcohol in an undivided cell in the presence of sodium bromide as mediator results in fast and efficient cyclization with the formation of the substituted spirocyclopropylpyrazolones in 60-90% substance yield. The fast (35 min) electrocatalytic reaction smoothly proceeds under neutral and mild conditions. The implication of electrocatalysis in cascade cyclization reaction is an efficient approach to medicinally relevant spirocyclopropylpyrazolones and is beneficial from the viewpoint of 'green chemistry' and diversity-oriented large-scale processes. (C) 2015 Elsevier Ltd. All rights reserved.
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