Journal
MOLECULES
Volume 22, Issue 2, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules22020321
Keywords
neoflavonoids; 4-phenyl-chromen-one; AIDS; Tat protein; NF-B inhibition; anti-HIV activity
Funding
- Spanish Ministry of Economy and Competitiveness
- Instituto de Salud Carlos III [PI16/CIII/034]
- Spanish AIDS Research Network [RD16CIII/0002/0001]
- ISCIII-Subdireccion General de Evaluacion and European Funding for Regional Development (FEDER)
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Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-B and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 M. The assays of these synthetic 4-phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.
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