Journal
MOLECULES
Volume 22, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules22020299
Keywords
amentoflavone; biflavonoid; natural derivatives; pharmacokinetics; pharmacology; phytochemistry
Funding
- National Natural Science Foundation of China [81173547]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD-2014]
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions [TAPP-PPZY2015A070]
- Key Research Project of Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization [ZDXM-1-3]
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Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future.
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