Journal
MOLECULES
Volume 22, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/molecules22040557
Keywords
Streptomyces antibioticus; secondary metabolite; strain identification; neoantimycins A and B; ECD calculations; cytotoxicity; antifungal activity
Funding
- National Natural Science Foundation of China [81373320]
- Guangdong Natural Science Funds [2015A030312002]
- Fundamental Research Funds for the Central Universities in Jinan University [21612114]
- Jinan University
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An actinomycete strain (H12-15) isolated from a sea sediment in a mangrove district was identified as Streptomyces antibioticus on the basis of 16S rDNA gene sequence analysis as well as the investigation of its morphological, physiological, and biochemical characteristics. Two novel benzamido nonacyclic dilactones, namely neoantimycins A (1) and B (2), together with the known antimycins A(1ab) (3a, b), A(2a) (4), and A(9) (5), were isolated from the culture broth of this strain. Compounds 1 and 2 are the first natural modified ATNs with an unusual benzamide unit. The structures of these new compounds, including their absolute configuration, were established on the basis of HRMS, NMR spectroscopic data, and quantum chemical ECD calculations. Their cytotoxicities against human breast adenocarcinoma cell line MCF-7, the human glioblastoma cell line SF-268, and the human lung cancer cell line NCI-H460 were also tested. All compounds exhibited mild cytotoxic activity. However, Compounds 1 and 2 showed no activity against C. albicans at the test concentration of 1 mg/mL via paper disc diffusion, while the known antimycins showed obvious antifungal activity.
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