Journal
MOLECULES
Volume 22, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/molecules22071166
Keywords
endophytic fungi; co-culture; pyridone; tetramic acid; Hawaii
Funding
- University of Hawaii Cancer Center
- University of Hawaii at Hilo
- Victoria S. and Bradley L. Geist Foundation [15ADVC-74420, 17CON- 86295]
- National Institutes of Health (NIH)/National Cancer Institute (NCI) [CA128865]
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A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of 1 was determined by comparison with the experimental and calculated ECD spectra. The absolute configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of the optical rotation and CD spectrum with those of 1. The other known compounds were identified as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with an IC50 value of 22 mu M.
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