Journal
MOLECULES
Volume 22, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/molecules22081328
Keywords
peptides; Michael addition; asymmetric organocatalysis; solvent-free reactions
Funding
- Consejo Nacional de Ciencia Y Tecnologia (CONACYT) [220945]
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The application of six novel alpha,beta-dipeptides as chiral organocatalysts in the asymmetric Michael addition reaction between enolizable aldehydes and N-arylmaleimides or nitroolefins is described. With N-arylmaleimides as substrates, the best results were achieved with dipeptide 2 as a catalyst in the presence of aq. NaOH. Whereas dipeptides 4 and 6 in conjunction with 4-dimethylaminopyridine (DMAP) and thiourea as a hydrogen bond donor proved to be highly efficient organocatalytic systems in the enantioselective reaction between isobutyraldehyde and various nitroolefins.
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