Journal
MOLECULES
Volume 22, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/molecules22081315
Keywords
purple sweet potato color; hepatic inflammation; NAD(+); NLRP3 inflammasome; high-fat diet
Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- National Natural Science Foundation of China [81570531, 81571055]
- China Agriculture Research System-sweetpotato [CARS-10]
- Key Research and Development Plan of Jiangsu Province [BE2015313]
- Scientific Research Support Project for Teachers with Doctor's Degrees [15XLR005]
- Natural Science Foundation of Jiangsu Province [BK20131127]
- Graduate Student Innovation Program of Jiangsu Province [KYZZ_0395, KYZZ16_0467]
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Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, exhibits beneficial effects on metabolic syndrome. Sustained inflammation plays a crucial role in the pathogenesis of metabolic syndrome. Here we explored the effects of PSPC on high-fat diet (HFD)-induced hepatic inflammation and the mechanisms underlying these effects. Mice were divided into four groups: Control group, HFD group, HFD + PSPC group, and PSPC group. PSPC was administered by daily oral gavage at doses of 700 mg/kg/day for 20 weeks. Nicotinamide riboside (NR) was used to increase NAD(+) levels. Our results showed that PSPC effectively ameliorated obesity and liver injuries in HFD-fed mice. Moreover, PSPC notably blocked hepatic oxidative stress in HFD-treated mice. Furthermore, PSPC dramatically restored NAD(+) level to abate endoplasmic reticulum stress (ER stress) in HFD-treated mouse livers, which was confirmed by NR treatment. Consequently, PSPC remarkably suppressed the nuclear factor-kappa B (NF-kappa B) p65 nuclear translocation and nucleotide oligomerization domain protein1/2 (NOD1/2) signaling in HFD-treated mouse livers. Thereby, PSPC markedly diminished the NLR family, pyrin domain containing 3 (NLRP3) inflammasome activation, ultimately lowering the expressions of inflammation-related genes in HFD-treated mouse livers. In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD(+) level to inhibit NLRP3 inflammasome activation.
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