Journal
MOLECULES
Volume 22, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/molecules22050765
Keywords
Alternaria sp.; endophytic fungus; Morinda officinalis; cytotoxicity; alpha-glucosidase inhibitory
Funding
- National Natural Science Foundation of China [31600271]
- Basic Research Program of China (973 Program) [2014CB460613]
- Guangdong Provincial Project for Science and Technology [2014A030304050, 2015A030302060]
- Natural Science Foundation of Guangdong Province [2015A030313710]
- GDAS' Special Project of Science and Technology Development [2017GDASCX-0819]
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Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (3-13) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis. Among them, the indandione (2) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the compounds were evaluated with cytotoxic and alpha-glucosidase inhibitory activity assays. Compounds 11 and 12 showed significant inhibitory activities against four tumor cell lines; MCF-7, HepG-2, NCI-H460 and SF-268, with IC50 values in the range of 1.91-9.67 mu M, and compounds 4, 5, 9, 10, 12 and 13 showed excellent inhibitory activities against alpha-glucosidase with IC50 values in the range of 12.05-166.13 mu M.
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