Journal
MOLECULES
Volume 22, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/molecules22050742
Keywords
celastrol; indole; Friedel-Crafts alkylation; AlCl3 center dot 6H(2)O
Funding
- National Nature Science Fund of China [NSFC-81301888, NSF-81672749, NSFC-31271453, NSFC-31471318, NSFC-91429306, U1405229, NSFC-91129302]
- Fundamental Research Funds for the Central Universities [2013121038]
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A classical Friedel-Crafts alkylation of different indoles catalyzed by AlCl3 center dot 6H(2)O has been developed for a well-known important natural product, celastrol, resulting in a series of derivatives for further biological evaluation. The catalyst loading was reduced to 5 mol %, the reaction proceeds at ambient temperature and reaction time is only 3 h. The product yields range from 20% to 99%. A reaction mechanism is also proposed, based on our experiment results.
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