Journal
MOLECULES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules22122072
Keywords
phenol; ethyl acetoacetate; solvent-free; microwave irradiation; heterogeneous acid catalysts
Funding
- Ministry of Education, Culture and Sport (MECD)
- Ramon Areces Foundation
- Andalusian Regional Government [FQM-346]
- Spanish Ministry of Economy and Competitiveness [MAT2013-44463-R]
- Feder Funds
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A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materialsAmberlyst-15, zeolite and sulfonic acid functionalized hybrid silicain solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions.
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