Journal
MOLECULES
Volume 22, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/molecules22111932
Keywords
cardiac glycosides; anticancer; immunogenic cell death; cytotoxic effects; cancer cells; Na/K-ATPase
Funding
- CAPES/MEC (Ministry of Education)
- CNPq/MCTIC (Ministry of Science, Technology and Innovation)
- Action Lions Vaincre le Cancer
- BK21
- Televie
- National Research Foundation (NRF) by the MEST of Korea [2012-0001184]
- Seoul National University (SNU) [370C-20160062]
- Brain Korea (BK21) PLUS program
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg association
- Een Haerz fir kriibskrank Kanner association
- Action LIONS Vaincre le Cancer association
- Televie Luxembourg
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Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.
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