Journal
MOLECULAR PSYCHIATRY
Volume 23, Issue 7, Pages 1575-1583Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2017.189
Keywords
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Funding
- BBSRC
- Medical Research Council (MRC)
- Age UK (Disconnected Mind Project)
- MRC [MR/M013111/1]
- Wellcome Trust Strategic Award [104036/Z/14/Z]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- MRC [MR/R024065/1, MC_UU_12011/2, MC_UP_A620_1015] Funding Source: UKRI
- Wellcome Trust [104036/Z/14/Z] Funding Source: Wellcome Trust
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The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.9% (part A), 22.4% (part B) and 17.6% (part B-part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (r(g)>40.6), general cognitive function (r(g)>40.6), processing speed (r(g)>40.7) and memory (r(g)>40.3). Polygenic profile analysis indicated considerable shared genetic aetiology between trail making, general cognitive function, processing speed and memory (standardized beta between 0.03 and 0.08). These results suggest that trail making is both phenotypically and genetically strongly associated with general cognitive function and processing speed.
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