Journal
MOLECULAR PHARMACEUTICS
Volume 14, Issue 5, Pages 1821-1830Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.7b00108
Keywords
phosphorus dendrimer; rose bengal; photosensitizer; photodynamic therapy; basal cell carcinoma; phototoxicity
Funding
- project Phosphorus dendrimers as carriers of photosensitizers in photodynamic therapy and its combination with hyperthermia in in vitro studies within Foundation for Polish Science VENTURES Programme (Project VENTURES) by Fund [VENTURES/ 2013-11/3]
- HARMONIA Studying phosphorus dendrimers as systems transporting photosensitizers Grant - National Science Centre [UMO-2013/08/M/NZ1/00761]
Ask authors/readers for more resources
In the last couple of decades, photodynamic therapy emerged as a useful tool in the treatment of basal cell carcinoma. However, it still meets limitation's due to unfavorableproperties of photosensitizers such as poor solubility or lack of selectivity. Dendrimers; polymers widely studied in biomedical field, may play a role as photosensitizer carriers and improve the efficacy of photodynamic treatment. Here, we describe the, evaluation-of an electrostatic complex of cationic phosphorus dendrimer and rose bengal in such aspects as singlet oxygen production, cellular uptake, and phototoxicity against three basal cell carcinoma cell lines. Rose bengal cationic dendrimer complex in molar ratio 5:1 was compared to free rose bengal. Obtained results showed that the singlet oxygen production in aqueous medium was significantly higher for the complex than for free rose bengal. The cellular uptake of the complex was 2-7 fold higher compared to a free,photosensitizer. Importantly, rose bengal, rose bengal-dendrimer complex, and dendrimer itself showed no dark toxicity against all three cell lines. Moreover, we observed that phototoxicity of the complex was remarkably enhanced presumably due to high cellular uptake. On the basis of the obtained results, we conclude that rose bengal cationic dendrimer complex has a potential in photodynamic treatment of basal cell carcinoma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available