Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 16, Issue 2, Pages 292-301Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.28047
Keywords
noncoding RNA; circRNA; cancer; biomarker; therapy
Categories
Funding
- National Key Research and Development Plan of China [2016YFA0502203]
- National Foundation of China [81670534]
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Circular (circ)RNAs, a newly recognized class of noncoding RNA, have been implicated in the occurrence and development of several diseases, including neurological and cardiovascular diseases. Studies of human tumors, including those of liver cancer, gastric cancer, lung cancer and colorectal cancer, have shown differential expression profiles of circRNAs, suggesting regulatory roles in cancer pathogenesis and metastasis. In this review, we discuss the most recent research into tumor-related circRNAs, providing a comprehensive summary of the expression or/and function of these circRNAs and proposing rational perspectives on the potential clinical application of circRNAs as helpful biomarkers or therapeutic targets in human tumors.
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