Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 61, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201600993
Keywords
Atherosclerosis; Cellular adhesion molecules; Inflammation; transcis-Lycopene isomers; Tomato juice
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Funding
- CICYT [AGL2010-22319-C3, AGL2013-49083-C3-1-R, AGL2016-79113-R]
- Instituto de Salud Carlos III, ISCIII (CIBERobn) from the Ministerio de Economia y Competitividad (MEC)
- Generalitat de Catalunya (GC) [2014 SGR 773]
- Juan de la Cierva postdoctoral program [FJCI-2015-25075]
- University of Barcelona
- Sara Borrell postdoctoral program [CD10/00151]
- Research Foundation on Wine and Nutrition (FIVIN)
- Cerveceros de Espana
- Sanofi-Aventis
- Novartis
- FIVIN
- PepsiCo
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Scope: The effect of carotenoids from tomato juice (TJ) on inflammatory biomarkers was evaluated by performing a 4-week dose-response nutritional trial in a population at high cardiovascular risk. Methods and results: An open, prospective, randomized, cross-over, and controlled clinical trial was carried out with 28 volunteers (mean age 69.7 +/- 3.1 years; mean BMI 31.5 +/- 3.6 kg/m(2)) at high cardiovascular risk, which were assigned to consume daily for 4 weeks in random order: 200 mL (LD) or 400 mL (HD) of TJ, or water as a control (C), with a 21-day wash-out period between each intervention. Blood samples were collected at baseline (B) and after each intervention. Endpoints included significant changes in plasmatic carotenoids, and adhesion molecules ICAM-1, and VCAM-1, as well as a tendency to decrease the chemokine IL-8. Compared to C, concentration of ICAM-1, and VCAM-1 were significantly lower (p ? 0.001), after each TJ intervention. Decreases were correlated remarkably with the trans-lycopene, while the other carotenoids present in TJ have presented a minor association or no association with changes in these molecules. Conclusion: trans-Lycopene from TJ may attenuate the risk of cardiovascular disease by reducing the concentration of important inflammatory molecules related to atherosclerosis.
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