Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 61, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201601029
Keywords
Advanced glycation end products; Dietary fat; Inflammation; Metabolic syndrome; Oxidative stress
Categories
Funding
- Ministerio de Economia y Competitividad [AGL2012/39615, PIE14/00005, PIE14/00031]
- Consejeria de Salud, Junta de Andalucia [PI0193/09]
- Proyecto de Excelencia, Consejeria de Economia, Innovacion, Ciencia y Empleo [CVI-7450]
- European Community (NUTRITECH European Integrated Project) [289511]
- Fondo Europeo de Desarrollo Regional (FEDER)
- Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979, AGL2009-12270]
- Ministerio de Ciencia y Competitividad [PIE14/00005, PIE14/00031, AGL2012-39615, FIS PI10/01041, FIS PI13/00023]
- Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425, PI-0193/09, PI-0252/09, PI-0058/10]
- Merck Serono
- Fundacion 2000 (Clinical research in Cardiometabolic)
- Science Foundation Ireland [SFI PI/11/1119]
- European Commission FP6 [FOOD-CT-2003-505944]
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Scope: Advanced glycation end products (AGEs) increase in dysmetabolic conditions. Lifestyle, including diet, has shown be effective in preventing the development of metabolic syndrome (MetS). We investigated whether AGE metabolism is affected by diets with different fat quantity and quality in MetS patients. Methods and results: A randomized, controlled trial assigned 75 MetS patients to one of four diets: high SFA (HSFA), high MUFA (HMUFA), and two low-fat, high-complex carbohydrate diets (LFHCC) supplemented with long-chain n-3 PUFA or placebo for 12-weeks each. Dietary and serum AGE [methylglyoxal (MG: lysine-MG-H1) and N-carboxymethyllysine] levels and gene expression related to AGE metabolism in peripheral blood mononuclear cells (AGER1, RAGE, GloxI, and Sirt1 mRNA) were determined. HMUFA diet reduced serum AGE (sAGE) and RAGE mRNA, increased AGER1 and GloxI mRNA levels compared to the other diets. LFHCC n-3 diet reduced sAGE levels and increased AGER1mRNA levels compared to LFHCC and HSFA diets. Multiple regression analyses showed that sMG and AGER1 mRNA appeared as significant predictors of oxidative stress/ inflammation-related parameters. Conclusions: Low AGE content in HMUFA diet reduces sAGEs and modulates the gene expression related to AGE metabolism in MetS patients, which may be used as a therapeutic approach to reduce the incidence of MetS and related chronic diseases.
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