Journal
MOLECULAR NEUROBIOLOGY
Volume 55, Issue 2, Pages 1045-1053Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-016-0356-7
Keywords
Sepsis; Blood brain barrier; Blood-cerebrospinal fluid barrier; Neuroinflammation; Microglial activation
Categories
Funding
- Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth)
- CNPq
- FAPESC
- Instituto Cerebro e Mente
- UNESC
- UNISUL
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The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier's permeability is not only a cause but a consequence of brain injury in sepsis.
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