Journal
MOLECULAR NEUROBIOLOGY
Volume 55, Issue 4, Pages 3513-3522Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-017-0594-3
Keywords
BDNF; Brain; Interleukin-6; Neuron; Neurotrophin; STAT3
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Funding
- Hanyang University
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2013R1A1A2009178]
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In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).
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