Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 1, Pages 14-19Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00519
Keywords
mitochondria; graphene oxide; nanoparticle; cisplatin; DNA damage; cancer
Funding
- Department of Biotechnology (DBT) [BT/RLF/Re-entry/13/2011, BT/PR14724/NNT/28/831/2015]
- DST-Nanomission [SB/NM/NB-1083/2017 (G)]
- CSIR-UGC
- IISER-Pune
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Mitochondrion, the powerhouse of the cells, controls bioenergetics, biosynthesis, metabolism, and signaling. Consequently, it has become an unorthodox target for cancer therapeutics. However, specific targeting of mitochondria into subcellular milieu in cancer cells remains a major challenge. To address this, we have engineered polyethylenimine cloaked positively charged self-assembled graphene oxide nanoparticle (PEI-GTC-NP) comprising topotecan and cisplatin concurrently. These PEI-GTC-NPs effectively homed into mitochondria in HeLa cervical cancer cells at 6 h and impaired mitochondria leading to reactive oxygen species generation followed by remarkably improved cancer cell death. This platform can be used for specific subcellular organelle targeting for future cancer therapy.
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