Journal
NEW JOURNAL OF CHEMISTRY
Volume 43, Issue 2, Pages 584-592Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj04669g
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Funding
- BRNS (Board of Research in Nuclear Sciences), India [37(2)/14/05/2016]
- DBT [BT/PR15214/BRB/10/1449/2015, BT/RLF/Re-entry/45/2015]
- DST-SERB [ECR/2016/000913]
- IIT Gandhinagar
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Two water-soluble compounds based on a coumarin-pyridinium scaffold were synthesized for rapid and selective detection of sulfite. The detection strategy is possible through a Michael addition reaction of the sulfite to the cyano-vinyl double bond, distinguishable through the hypsochromic shifts in absorption and emission maxima. The probes exhibited high selectivity for sulfite, with a detection limit of 1.47 M for dye 1 and 2.8 M for dye 2 and a near instant response time of 10-20 seconds over other analytes and reactive sulfur species. Importantly, the probes also exhibit a robust colorimetric response in the presence of sulfite. Cellular imaging studies have demonstrated that the probes are non-toxic and suitable for the detection of sulfite levels in cells. Additionally, the probes have demonstrated sensitivity to detect endogenous sulfite levels in hepatic cancer cells.
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