4.7 Review

Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

Journal

JCI INSIGHT
Volume 4, Issue 2, Pages -

Publisher

AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.124061

Keywords

-

Funding

  1. National Institute of General Medical Sciences [R01GM115605, K08GM102695]
  2. NHLBI [R56HL142767]
  3. American Thoracic Society Research Foundation
  4. Central Society for Clinical and Translational Research

Ask authors/readers for more resources

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host response to infection leads to disruption of the pulmonary alveolar-capillary barrier, resulting in lung injury characterized by hypoxemia, inflammation, and noncardiogenic pulmonary edema. Despite increased understanding of the molecular biology underlying sepsis-induced ARDS, there are no targeted pharmacologic therapies for this devastating condition. Here, we review the molecular underpinnings of sepsis-induced ARDS with a focus on relevant clinical and translational studies that point toward novel therapeutic strategies.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available