Journal
MOLECULAR MEDICINE REPORTS
Volume 16, Issue 2, Pages 1071-1078Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2017.6688
Keywords
small protein A; phospholipase D; protective role; Acinetobacter baumannii
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Funding
- China Hunan Provincial Science and Technology Department [2015SK20401]
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Acinetobacter baumannii is an important pathogen that primarily causes hospital-acquired pneumonia. The present study sought to investigate whether small protein A (SmpA) and phospholipase D (PLD) are potential candidates for protective immunity against infection with A. baumannii. Mice immunized with the fusion proteins histidine (His)-SmpA and His-PLD exhibited a specific immunoglobulin G response. In a pneumonia model, active and passive immunization against SmpA and PLD protected mice from A. baumannii infection. The protection was demonstrated by a markedly improved survival rate, and reduced pulmonary bacterial load, infiltration and cytokine levels in the broncho-alveolar lavage fluid and the serum, although a combination of the two antigens did not provide improved protection compared with immunization with the individual antigens alone. In conclusion, it was identified that SmpA and PLD are highly immunogenic proteins, and potential antigen candidates for the development of effective vaccines or to prepare antisera to mitigate A. baumannii infection.
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