Journal
MOLECULAR MEDICINE REPORTS
Volume 15, Issue 5, Pages 3379-3382Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2017.6385
Keywords
non-Hodgkin's lymphoma; BCL2; B-cell; occupational exposure; greenhouse; fungicides; insecticides; carcinogenicity; cancer
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Exposure to pesticides represents a potential health risk for the general population and for agricultural workers in particular. Some researchers observed that occupational exposure to pesticides is associated with risk of non-Hodgkin's lymphoma (NHL). The chromosomal translocation t(14;18) (q32;q21) is one of the most common chromosomal abnormalities in NHL. The aim of this study was to detect the effects of pesticides on t(14;18) chromosome translocation in agricultural workers after short-term exposure. Fifty-two workers occupationally exposed to pesticides (fungicides and insecticides) and 52 non-exposed were recruited. The farm workers were on average exposed to pesticides for similar to 3.7 h a day for 5 years. The frequency of BCL2-IGH t(14;18) translocation in workers occupationally exposed to pesticides was 10% (5 of 52) vs. 8% (4 of 52) in the control group. Overall, these data suggest that no significant association between occupational exposure to pesticides and an increased frequency of the chromosomal translocation BCL2-IGH t(14;18) in farmers was observed. However, further studies with a higher number of subjects exposed to pesticides are necessary to confirm this observation.
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