Journal
NEURAL REGENERATION RESEARCH
Volume 14, Issue 4, Pages 642-648Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.247468
Keywords
nerve regeneration; neonates; hypoxic ischemic encephalopathy; resting-state functional magnetic resonance imaging; brain networks; small-world organization; brain functional connectivity; local efficiency; clustering coefficient; neural regeneration
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Funding
- Jiangsu Maternal and Child Health Research Project of China [F201612]
- Changzhou Science and Technology Support Plan of China [CE20165027]
- Changzhou City Planning Commission Major Science and Technology Projects of China [ZD201515]
- Changzhou High Level Training Fund for Health Professionals of China [2016CZBJ028]
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Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 term-born infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function.
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