Journal
MOLECULAR IMMUNOLOGY
Volume 85, Issue -, Pages 123-129Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2017.02.009
Keywords
IRF9; TRIF; Negative regulation; NF-kappa B; Teleost
Categories
Funding
- National Natural Science Foundation of China [31370049, 31672682]
- Natural Science Foundation of Zhejiang Province [LR14C040001]
Ask authors/readers for more resources
Proinflammatory cytokines and type I IFNs were produced by TLR signaling and these responses are crucial for host defensive responses against pathogens. In order to avoid harmful and inappropriate inflammatory responses, there are multiple mechanisms to negatively regulate TLR signaling. In this paper, we have firstly studied IRF9 functions as a negative regulator involved in TRIF-mediated NF-kappa B pathway. Moreover, we found inhibitory effect of IRF9 primary depends on DBD domain. Interestingly, we also demonstrated that else mutants of IRF9, except for IRF9-Delta DBD, have different inhibitory effects upon TRIF-mediated NF-kappa B pathway. This study provides a novel evidence about the negatively regulation of innate immune signaling pathway in teleost fish. In addition, this finding provides new insights into the regulatory mechanism in mammals. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available