Journal
MOLECULAR IMMUNOLOGY
Volume 91, Issue -, Pages 123-133Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2017.09.001
Keywords
Gold nanoparticles; Dendritic cells; Maturation; T cells; Cytokine
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Funding
- Universiti Sains Malaysia (USM) Short Term Grant [304.PPSP.61313138]
- Fundamental Research Grant Scheme (FRGS) by Ministry of Higher Education (MOHE) Malaysia [203.PPSP.6171198]
- Research Assistant Scheme under USM Short Term Grant
- MyBrain15 scholarship under MOHE
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Gold nanoparticles (NPs) have been proposed as a highly potential tool in immunotherapies due to its advantageous properties including customizable size and shapes, surface functionality and biocompatibility. Dendritic cells (DCs), the sentinels of immune response, have been of interest to be manipulated by using gold NPs for targeted delivery of immunotherapeutic agent. Researches done especially in human DCs showed a variation of gold NPs effects on cellular uptake and internalization, DC maturation and subsequent T cells priming as well as cytotoxicity. In this review, we describe the synthesis and physiochemical properties of gold NPs as well as the importance of gold NPs in immunotherapies through their actions on human DCs.
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