Journal
FUTURE SCIENCE OA
Volume 5, Issue 1, Pages -Publisher
FUTURE SCI LTD
DOI: 10.4155/fsoa-2017-0054
Keywords
contrast agent; Endorem (R); liver; magnetic resonance imaging; MRI; SPIONs; superparamagnetic iron oxide nanoparticles; toxicity; uptake
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Funding
- Spanish Ministry of Science and Innovation [MAT2014-54975-R]
- Programa Operativo FEDER Aragon 2014-2020 'Construyendo Europa desde Aragon'
- Diputacion General de Aragon (DGA-M4)
- Spanish Ministry of Science and Innovation FPI research grants
- Fondazione Cariverona (Verona, Italy) through the project 'Verona Nanomedicine Initiative'
- MIUR through FIRB project [RBAP114AMK]
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Aim: To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T-2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem (R). The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T-2 contrast agent with a higher r(2)/r(1) ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection. Lay abstract: Several superparamagnetic iron oxide nanoparticles (SPIONs) preparations have been approved by US FDA for clinical use as MRI contrast agents. In recent years, we have been developing a synthetic multifunctional platform for SPIONs based on the use of polymers. In this report, we explored the diagnostic potential of these nanoparticles (herein called bioferrofluids) as an MRI contrast agent and their uptake in liver, without neglecting their toxicological effects. Results show that our bioferrofluids are a good T-2 contrast agent without any observed toxicity in liver.
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