4.5 Article

Iodine-mediated sp3 C-H functionalization of methyl ketones: a one-pot synthesis of functionalized indolizines via the 1,3-dipolar cycloaddition reaction between pyridinium ylides and ynones

Journal

MOLECULAR DIVERSITY
Volume 21, Issue 1, Pages 1-8

Publisher

SPRINGER
DOI: 10.1007/s11030-016-9720-9

Keywords

C-H activation; 1, 3-Dipolar cycloaddition; N-ylides; Indolizines; Iodine; Ynones

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An efficient transition-metal-free approach toward C-H bond activation by using molecular -mediated C-H bond functionalization for the synthesis of indolizine derivatives via 1,3-dipolar cycloaddition reaction of nitrogen ylides with ynones is described. [GRAPHICS]

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