Journal
MOLECULAR CELL
Volume 66, Issue 6, Pages 801-817Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2017.05.015
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Funding
- Cancer Research UK (CRUK) [C29215/A20772]
- CRUK program [C6/A18796]
- Wellcome Trust [206388/Z/ 17/Z, WT092096]
- CRUK [C6946/A14492, C4750/A21839]
- University of Cambridge, UK
- Cancer Research UK [18796, 20772] Funding Source: researchfish
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In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established functions in sensing and responding to genotoxic stress. We also highlight what is known regarding their structural similarities andcommon mechanisms of regulation, as well asemerging non-canonical roles and how our knowledge of ATM, ATR, and DNA-PK is being translated to benefit human health.
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