Journal
MOLECULAR CELL
Volume 65, Issue 6, Pages 965-973Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2017.02.024
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Funding
- Science Foundation Ireland [14/IA/ 2622]
- Worldwide Cancer Research [14-0323]
- Science Foundation Ireland (SFI) [14/IA/2622] Funding Source: Science Foundation Ireland (SFI)
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Necroptosis (programmed necrosis) occurs in response to TNF, Fas, or TRAIL, as well as certain TLR ligands, when caspase activity required for apoptosis is blocked. Necroptosis is typically considered a highly pro-inflammatory mode of cell death, due to release of intracellular danger signals'' that promote inflammation. However, because most pro-necroptotic stimuli are intrinsically highly pro-inflammatory-due to their ability to initiate the synthesis of numerous cytokines and chemokines-the inflammatory consequences of necroptosis are complex. Here, we suggest that necroptosis might have anti-inflammatory effects in certain settings, through curbing excessive TNF- or TLR-induced inflammatory cytokine production.
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