Journal
MOLECULAR CELL
Volume 66, Issue 6, Pages 772-779Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2017.06.002
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute
- Breast Cancer Research Foundation
- NIH [R35CA210068, P50CA165962, P50CA101942, R01CA155332]
- Fibrogen
- Peloton Therapeutics
Ask authors/readers for more resources
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIF alpha subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available