Journal
MOLECULAR CARCINOGENESIS
Volume 56, Issue 8, Pages 1896-1908Publisher
WILEY
DOI: 10.1002/mc.22645
Keywords
cancer metastasis; metapristone; mifepristone (RU486); ovarian cancer; the CXCL12; CXCR4 chemokine axis
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Funding
- National Natural Science Foundation of China (NSFC) [U1505225, 81273548]
- Fujian Development and Reform Commission Project [829054]
- Ministry of Science and Technology of China [2015CB931804]
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Recent global epidemiological studies revealed the lower ovarian cancer death from long-term use of oral contraceptives. However, the underlying mechanism of action is not clear. Here, we use the abortifacient metapristone (RU486 derivative) to test the hypothesis that the contraceptives might interrupt CXCL12/CXCR4 chemokine axis to inhibit ovarian cancer metastasis. Metapristone at concentrations (
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