Journal
MOLECULAR CARCINOGENESIS
Volume 56, Issue 7, Pages 1712-1721Publisher
WILEY
DOI: 10.1002/mc.22628
Keywords
CD133; CSCs; DKK3; gastric cancer; NK cells
Categories
Funding
- National Natural Scientific Foundation of China [81572777, 81502558]
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Cancer stem cell (CSCs) has started a new era in cancer research. CD133 is a widely used marker for identification of CSCs. More and more studies showed that NK cells preferentially target cancer stem-like cells. However, the deeper mechanism of the susceptibility of cancer stem cells to NK cells remains unclear. In this study, we isolated CD133 positive population of a gastric cancer cell line, BGC823 cells, and cultured with NK cells. We found that CD133 could efficiently active NK cells in an NKG2D-dependent manner. DKK3 has been demonstrated as a suppressor in many cancers. Interestingly, we found that DKK3 suppressed CD133-induced activation in NK cells by inhibiting Erk pathway and immunological synapse (IS) formation. NK cells-based CSCs immunotherapy may be a novel approach for cancer therapy.
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