Journal
MOLECULAR CANCER
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12943-017-0624-9
Keywords
Pancreatic cancer; Cancer stem cell; Epithelial-to-mesenchymal transition; Resistance
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Funding
- National Natural Science Foundation of China [81370600]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [TP2015022]
- Shanghai Pujiang Program [15PJ1404800]
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The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy.
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