Journal
MOLECULAR CANCER
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12943-017-0707-7
Keywords
Neutrophils; Neutrophil-lymphocyte ratio; Prognosis; Target
Categories
Funding
- Instituto de Salud Carlos III, ACEPAIN [PI16/01121]
- Diputacion de Albacete
- CRIS Cancer Foundation
- Ministry of Economy and Competitiveness of Spain [BFU2015-71371-R]
- Instituto de Salud Carlos III through the Spanish Cancer Centers Network Program [RD12/0036/0003]
- CIBERONC
- scientific foundation of the AECC
- CRIS Foundation
- European Community
- BAE (Beca Ampliacion de Estudios)
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Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently under clinical development. Here, we review some of the relevant literature of the role of neutrophils in different stages of the oncogenic process including tumor initiation, growth, proliferation or metastatic spreading and also focus on how neutrophil counts or the neutrophil-to-lymphocyte ratio may be used as a prognostic and predictive biomarker. Strategies to avoid the deleterious effects of neutrophils in cancer and to reduce their activity are discussed. Examples for such strategies include inhibition of CXCR1 and CXCR2 to decrease migration of neutrophils to tumoral areas or the inhibition of granulocyte colony stimulating factor to decrease the amount of neutrophils which has shown efficacy in preclinical models.
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