4.7 Review

Tumor-related interleukins: old validated targets for new anti-cancer drug development

Related references

Note: Only part of the references are listed.
Article Oncology

Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells

Ibrahim M. Sektioglu et al.

CANCER RESEARCH (2017)

Article Dentistry, Oral Surgery & Medicine

IL-1 maintains the redox balance by regulating glutaredoxin 1 expression during oral carcinogenesis

Xijuan Chen et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2017)

Article Biochemistry & Molecular Biology

Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells

Stephanie Tsang Mui Chung et al.

MOLECULAR CANCER (2017)

Article Immunology

Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient

Rawan Kassar et al.

TRANSPLANT INFECTIOUS DISEASE (2017)

Review Oncology

Intralesional treatment of metastatic melanoma: a review of therapeutic options

Benjamin Weide et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

Article Biochemistry & Molecular Biology

Lewis Lung Cancer Cells Promote SIGNR1( CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion

Xiaolong Yan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2016)

Meeting Abstract Oncology

IL-4 / IL-13 mediated cell-to-cell fusion in prostate cancer progress

Berna Uygur et al.

CANCER RESEARCH (2016)

Article Oncology

IL-1 drives breast cancer growth and bone metastasis in vivo

Ingunn Holen et al.

ONCOTARGET (2016)

Article Multidisciplinary Sciences

Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice

Jing Hong et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag

Rachel Friedman Ohana et al.

ACS CHEMICAL BIOLOGY (2015)

Review Oncology

Targeting IL4/IL4R for the treatment of epithelial cancer metastasis

Katherine Venmar Bankaitis et al.

CLINICAL & EXPERIMENTAL METASTASIS (2015)

Article Dentistry, Oral Surgery & Medicine

TAMS and IL-6 contribute to resistance to radiotherapy in oral squamous cell carcinoma

Y. Matsuoka et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2015)

Article Urology & Nephrology

Inflammation and prostate cancer: the role of interleukin 6 (IL-6)

Daniel P. Nguyen et al.

BJU INTERNATIONAL (2014)

Review Biochemistry & Molecular Biology

Interleukin-6 and its receptors: A highly regulated and dynamic system

Janina Wolf et al.

CYTOKINE (2014)

Review Biochemistry & Molecular Biology

The IL-2 cytokine family in cancer immunotherapy

Geok Choo Sim et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2014)

Article Pharmacology & Pharmacy

Siltuximab: First Global Approval

Anthony Markham et al.

DRUGS (2014)

Article Medicine, Research & Experimental

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

Geok Choo Sim et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Gastroenterology & Hepatology

The origin of cancer stem cells

Hien T. Dang et al.

JOURNAL OF HEPATOLOGY (2014)

Article Immunology

IL-2: The First Effective Immunotherapy for Human Cancer

Steven A. Rosenberg

JOURNAL OF IMMUNOLOGY (2014)

Article Medicine, General & Internal

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Lisa A. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Pharmacology & Pharmacy

Targeting interleukin-6 in inflammatory autoimmune diseases and cancers

Xin Yao et al.

PHARMACOLOGY & THERAPEUTICS (2014)

Article Genetics & Heredity

Interleukin-15 in Gene Therapy of Cancer

Maria C. Ochoa et al.

CURRENT GENE THERAPY (2013)

Review Biochemistry & Molecular Biology

Osteoprotegerin: Multiple partners for multiple functions

Marc Baud'huin et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

Review Biotechnology & Applied Microbiology

Therapeutic modulators of STAT signalling for human diseases

Gabriella Miklossy et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Medicine, General & Internal

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

Sally Wenzel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Biochemistry & Molecular Biology

Targeting Interleukin-4 in Asthma: Lost in Translation?

Tania Maes et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

Review Cell Biology

Regulation of inflammation by interleukin-4: a review of alternatives

Irina G. Luzina et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2012)

Review Immunology

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Jacques Banchereau et al.

NATURE IMMUNOLOGY (2012)

Review Respiratory System

Targeting interleukins to treat severe asthma

David Gibeon et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2012)

Article Biotechnology & Applied Microbiology

A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer

Trevor J. Bayliss et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2011)

Review Immunology

Regulatory T cells and Foxp3

Alexander Y. Rudensky

IMMUNOLOGICAL REVIEWS (2011)

Article Oncology

Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor

Alfonso Quintas-Cardama et al.

INVESTIGATIONAL NEW DRUGS (2011)

Article Medicine, General & Internal

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

Douglas J. Schwartzentruber et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Multidisciplinary Sciences

Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression

Antonia Fettelschoss et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Oncology

Interleukin-6 in bone metastasis and cancer progression

Tasnim Ara et al.

EUROPEAN JOURNAL OF CANCER (2010)

Article Immunology

Leflunomide: a drug with a potential beyond rheumatology

Sven Teschner et al.

IMMUNOTHERAPY (2010)

Article Multidisciplinary Sciences

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

Carsten Krieg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Respiratory System

Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma

C. K. Oh et al.

EUROPEAN RESPIRATORY REVIEW (2010)

Article Oncology

A High-Affinity Fully Human Anti-IL-6 mAb, 1339, for the Treatment of Multiple Myeloma

Mariateresa Fulciniti et al.

CLINICAL CANCER RESEARCH (2009)

Review Oncology

Targeted therapies in multiple myeloma

Efstathios Kastritis et al.

TARGETED ONCOLOGY (2009)

Review Immunology

The biology of interleukin-2

Thomas R. Matek

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Sherry L. LaPorte et al.

Article Biochemistry & Molecular Biology

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

M. Todaro et al.

CELL DEATH AND DIFFERENTIATION (2008)

Review Pharmacology & Pharmacy

The blockade of IL-6 signaling in rational drug design

Yasuo Adachi et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Article Biochemistry & Molecular Biology

IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells

Wen Jie Zhang et al.

CYTOKINE (2008)

Review Immunology

Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy?

Ron N. Apte et al.

IMMUNOLOGICAL REVIEWS (2008)

Article Biotechnology & Applied Microbiology

IL-1 trap go-ahead

Mark Ratner

NATURE BIOTECHNOLOGY (2008)

Article Medicine, Research & Experimental

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Pasquale Sansone et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Cell & Tissue Engineering

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

Christophe Ginestier et al.

CELL STEM CELL (2007)

Article Cell & Tissue Engineering

Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4

Matilde Todaro et al.

CELL STEM CELL (2007)

Review Medicine, Research & Experimental

Inflammation, atrophy, and gastric cancer

James G. Fox et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Hematology

Differential regulation of T-cell growth by IL-2 and IL-15

Georgina H. Cornish et al.

BLOOD (2006)

Review Medicine, Research & Experimental

Role of osteoprotegerin (OPG) in cancer

I Holen et al.

CLINICAL SCIENCE (2006)

Article Oncology

The role of interleukin 1 in growth and metastasis of human cancer cenografts

DM Elaraj et al.

CLINICAL CANCER RESEARCH (2006)

Review Oncology

Paradoxical roles of the immune system during cancer development

KE de Visser et al.

NATURE REVIEWS CANCER (2006)

Review Biotechnology & Applied Microbiology

Exploiting the PI3K/AKT pathway for cancer drug discovery

BT Hennessy et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Multidisciplinary Sciences

The structure of interleukin-2 complexed with its alpha receptor

M Rickert et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Interieukin-6 regulation of prostate cancer cell growth

Z Culig et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2005)

Letter Oncology

Interleukin-6 and C-reactive protein in metastatic renal cell carcinoma

O Altundag et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Article Immunology

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

R Zeng et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Biochemistry & Molecular Biology

Suppression of cancer cachexia by 20S,21-epoxy-resibufogenin-3-acetate -: a novel nonpeptide IL-6 receptor antagonist

A Enomoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Multidisciplinary Sciences

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

S Nakae et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Gastroenterology & Hepatology

Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms

EM El-Omar et al.

GASTROENTEROLOGY (2003)

Article Oncology

Circulating interleukin-6 predicts survival in patients with metastatic breast cancer

R Salgado et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

Article Biochemistry & Molecular Biology

Cytokine traps: multi-component, high-affinity blockers of cytokine action

AN Economides et al.

NATURE MEDICINE (2003)

Review Oncology

NF-κB in cancer:: From innocent bystander to major culprit

M Karin et al.

NATURE REVIEWS CANCER (2002)

Review Medicine, General & Internal

Inflammation and cancer: back to Virchow?

F Balkwill et al.

LANCET (2001)

Article Medicine, Research & Experimental

Therapeutic potential of inhibition of the NF-kappa B pathway in the treatment of inflammation and cancer

Y Yamamoto et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Multidisciplinary Sciences

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

EM El-Omar et al.

NATURE (2000)