Journal
MOLECULAR CANCER
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12943-017-0637-4
Keywords
PinX1; Non-small cell lung cancer; BMP5; Cell cycle; P15
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Funding
- 973 Project of China [2010CB912802]
- National Nature Science Foundation of China [81603137]
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Background: The telomerase/telomere interacting protein PinX1 has been suggested as a tumor suppressor. However, the clinical and biological significance of PinX1 in human non-small cell lung cancer (NSCLC) is unclear. Methods: PinX1 gene/expression pattern and its association with NSCLC patient survival were analyzed in cBioportal Web resource and two cohorts of NSCLC samples. A series of in vivo and in vitro assays were performed to elucidate the function of PinX1 on NSCLC cells proliferation and underlying mechanisms. Results: More frequency of gene PinX1 homozygous deletion and heterozygote deficiency was first retrieved from cBioportal Web resource. Low expression of PinX1 correlated with smoking condition, histological type, T stage, N stage, M stage and TNM stage, and was an independent predictor for overall survival in a learning cohort (n = 93) and a validation cohort (n = 51) of NSCLC patients. Furthermore, knockdown of PinX1 dramatically accelerated NSCLC cell proliferation and G1/S transition, whereas ectopic overexpression of PinX1 substantially inhibited cell viability and cell cycle transition in vitro and in vivo. p15/cyclin D1 pathway and BMP5 might contribute to PinX1associated cell proliferation and cell cycle transition. Conclusion: The cost-effective expression of PinX1 could constitute a novel molecular predictor/marker for NSCLC management.
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