Journal
MOLECULAR BIOTECHNOLOGY
Volume 59, Issue 9-10, Pages 435-444Publisher
HUMANA PRESS INC
DOI: 10.1007/s12033-017-0024-9
Keywords
Transgenic pigs; Genetic engineering; Xenotransplantation; Genetically modified pigs; Genome modifications
Funding
- National Centre for Research and Development [INNOMED/I/17/NCBR/2014]
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The growing shortage of available organs is a major problem in transplantology. Thus, new and alternative sources of organs need to be found. One promising solution could be xenotransplantation, i.e., the use of animal cells, tissues and organs. The domestic pig is the optimum donor for such transplants. However, xenogeneic transplantation from pigs to humans involves high immune incompatibility and a complex rejection process. The rapid development of genetic engineering techniques enables genome modifications in pigs that reduce the cross-species immune barrier.
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