Related references
Note: Only part of the references are listed.A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis
Lauren Ray et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases
Wei -Hung Chen et al.
ACS CHEMICAL BIOLOGY (2016)
New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis
Tiia Kittilae et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo
Veit Weichold et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
An Activator of an Adenylation Domain Revealed by Activity but Not Sequence Homology
Shalini Saha et al.
CHEMBIOCHEM (2016)
Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases
Tiia Kittila et al.
CHEMBIOCHEM (2016)
Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins
Sophia Zobel et al.
CHEMBIOCHEM (2016)
Expanding Substrate Promiscuity by Engineering a Novel Adenylating-Methylating NRPS Bifunctional Enzyme
Sanjib K. Shrestha et al.
CHEMBIOCHEM (2016)
Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly
Ina Wilkening et al.
CHEMICAL COMMUNICATIONS (2016)
Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis
Madeleine Peschke et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)
Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture
Bradley R. Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Mapping of the Communication-Mediating Interface in Nonribosomal Peptide Synthetases Using a Genetically Encoded Photocrosslinker Supports an Upside-Down Helix-Hand Motif
Eva Dehling et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis
Madeleine Peschke et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH
Veronika Ulrich et al.
MOLECULAR BIOSYSTEMS (2016)
Recent advances in engineering nonribosomal peptide assembly lines
M. Winn et al.
NATURAL PRODUCT REPORTS (2016)
A structural model for multimodular NRPS assembly lines
Mohamed A. Marahiel
NATURAL PRODUCT REPORTS (2016)
Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?
Mark E. Horsman et al.
NATURAL PRODUCT REPORTS (2016)
Structures of two distinct conformations of holo-non-ribosomal peptide synthetases
Eric J. Drake et al.
NATURE (2016)
F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE
Madeleine Peschke et al.
SCIENTIFIC REPORTS (2016)
Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases
Kristjan Bloudoff et al.
CELL CHEMICAL BIOLOGY (2016)
Generating Functional Recombinant NRPS Enzymes in the Laboratory Setting via Peptidyl Carrier Protein Engineering
Jeremy G. Owen et al.
CELL CHEMICAL BIOLOGY (2016)
Structural Elucidation of the Bispecificity of A Domains as a Basis for Activating Non-natural Amino Acids
Heidi Kaljunen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis
Clara Brieke et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products
Rashed S. Al Toma et al.
NATURAL PRODUCT REPORTS (2015)
Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis
Kristin J. Labby et al.
NATURAL PRODUCT REPORTS (2015)
X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
Kristina Haslinger et al.
NATURE (2015)
β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis
Nicole M. Gaudelli et al.
NATURE (2015)
The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
Stephane Cociancich et al.
NATURE CHEMICAL BIOLOGY (2015)
The structural biology of biosynthetic megaenzymes
Kira J. Weissman
NATURE CHEMICAL BIOLOGY (2015)
Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics
Clara Brieke et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Reprogramming Nonribosomal Peptide Synthetases for Clickable Amino Acids
Hajo Kries et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase
Kristina Haslinger et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Chemical Probes for the Functionalization of Polyketide Intermediates
Elena Riva et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Prospects for new antibiotics: a molecule-centered perspective
Christopher T. Walsh et al.
JOURNAL OF ANTIBIOTICS (2014)
The Crystal Structure of the Adenylation Enzyme VinN Reveals a Unique β-Amino Acid Recognition Mechanism
Akimasa Miyanaga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Trapping the dynamic acyl carrier protein in fatty acid biosynthesis
Chi Nguyen et al.
NATURE (2014)
Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis
Nicole M. Gaudelli et al.
NATURE CHEMICAL BIOLOGY (2014)
A Facile Fmoc Solid Phase Synthesis Strategy To Access Epimerization-Prone Biosynthetic Intermediates of Glycopeptide Antibiotics
Clara Brieke et al.
ORGANIC LETTERS (2014)
Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases
Bradley R. Miller et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2014)
Combinatorial Biosynthesis of Cyclic Lipopeptide Antibiotics: A Model for Synthetic Biology To Accelerate the Evolution of Secondary Metabolite Biosynthetic Pathways
Richard H. Baltz
ACS SYNTHETIC BIOLOGY (2014)
Reconstituted Biosynthesis of the Nonribosomal Macrolactone Antibiotic Valinomycin in Escherichia coli
Jennifer Jaitzig et al.
ACS SYNTHETIC BIOLOGY (2014)
Structure of the epimerization domain of tyrocidine synthetase A
Stefan A. Samel et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2014)
Cytochrome P450sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis
Stefanie Uhlmann et al.
ACS CHEMICAL BIOLOGY (2013)
Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds
Christopher T. Walsh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases
Kristjan Bloudoff et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Stereocontrolled Syntheses of Peptide Thioesters Containing Modified Seryl Residues as Probes of Antibiotic Biosynthesis
Nicole M. Gaudelli et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Non-ribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on the MbtH Family Protein Nocl
Jeanne M. Davidsen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
The enzymes of beta-lactam biosynthesis
Refaat B. Hamed et al.
NATURAL PRODUCT REPORTS (2013)
Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity
Jenny Thirlway et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production
Wolfgang Wohlleben et al.
FEBS LETTERS (2012)
Diversity of P450 enzymes in the biosynthesis of natural products
Larissa M. Podust et al.
NATURAL PRODUCT REPORTS (2012)
Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology
Gene H. Hur et al.
NATURAL PRODUCT REPORTS (2012)
Cytochrome P450-catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis
Sarah M. Barry et al.
NATURE CHEMICAL BIOLOGY (2012)
Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases
Ye Liu et al.
CHEMISTRY & BIOLOGY (2011)
Role of MbtH-like Proteins in the Adenylation of Tyrosine during Aminocoumarin and Vancomycin Biosynthesis
Bjoern Boll et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Biosynthetic Gene Cluster of the Non-ribosomally Synthesized Cyclodepsipeptide Skyllamycin: Deciphering Unprecedented Ways of Unusual Hydroxylation Reactions
Stefan Pohle et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Carrier protein substrates in cytochrome P450-catalysed oxidation
Max J. Cryle
METALLOMICS (2011)
MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases
Elizabeth A. Felnagle et al.
BIOCHEMISTRY (2010)
Glycopeptide biosynthesis in the context of basic cellular functions
Evi Stegmann et al.
CURRENT OPINION IN MICROBIOLOGY (2010)
Structural Characterization of OxyD, a Cytochrome P450 Involved in β-Hydroxytyrosine Formation in Vancomycin Biosynthesis
Max J. Cryle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery
Lars Robbel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase
Andrew M. Gulick
ACS CHEMICAL BIOLOGY (2009)
From thioesters to amides and back: Condensation domain reversibility in the biosynthesis of vibriobactin
Carl J. Balibar et al.
CHEMBIOCHEM (2008)
Nonribosomal peptide synthetases involved in the production of medically relevant natural products
Elizabeth A. Felnagle et al.
MOLECULAR PHARMACEUTICS (2008)
A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth
Christopher T. Calderone et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450Biol ACP complex
Max J. Cryle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Crystal structure of the termination module of a nonribosomal peptide synthetase
Alan Tanovic et al.
SCIENCE (2008)
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula
Aishwarya V. Ramaswamy et al.
JOURNAL OF NATURAL PRODUCTS (2007)
In vitro synthesis of new enniatins:: Probing the α-D-hydroxy carboxylic acid binding pocket of the multienzyme enniatin synthetase
Sven C. Feifel et al.
CHEMBIOCHEM (2007)
The biosynthesis of teicoplanin-type glycopeptide antibiotics:: Assignment of p450 mono-oxygenases to side chain Cyclizations of glycopeptide a47934
Bianka Hadatsch et al.
CHEMISTRY & BIOLOGY (2007)
Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase
Stefan A. Samel et al.
STRUCTURE (2007)
Oxidative phenol coupling reactions catalyzed by OxyB: A cytochrome p450 from the vancomycin producing organism. Implications for vancomycin biosynthesis
Katharina Woithe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
A mechanism-based aryl carrier protein/thiolation domain affinity probe
Chunhua Qiao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
Christian Rausch et al.
BMC EVOLUTIONARY BIOLOGY (2007)
Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis
Hitoshi Takahashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Characterization of the cereulide NRPS α-hydroxy acid specifying modules:: Activation of α-keto acids and chiral reduction on the assembly line
Nathan A. Magarvey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
Michael A. Fischbach et al.
CHEMICAL REVIEWS (2006)
Genetic analysis of the balhimycin (vancomycin-type) oxygenase genes
Evi Stegmann et al.
JOURNAL OF BIOTECHNOLOGY (2006)
Cyanobacterial peptides -: Nature's own combinatorial biosynthesis
Martin Welker et al.
FEMS MICROBIOLOGY REVIEWS (2006)
Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides
M Hahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains
CJ Balibar et al.
CHEMISTRY & BIOLOGY (2005)
Utility of epimerization domains for the redesign of nonribosomal peptide synthetases
DB Stein et al.
FEBS JOURNAL (2005)
The biosynthesis of vancomycin-type glycopeptide antibiotics -: A model for oxidative side-chain cross-linking by oxygenases coupled to the action of peptide synthetases
D Bischoff et al.
CHEMBIOCHEM (2005)
Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates
GC Uguru et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains
N Kessler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
An oxidative phenol coupling reaction catalyzed by OxyB, a cytochrome p450 from the vancomycin-producing microorganism
K Zerbe et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Mutasynthesis of glycopeptide antibiotics:: Variations of vancomycin's AB-ring amino acid 3,5-dihydroxyphenylglycine
S Weist et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Reactions catalyzed by bacterial cytochromes P450
MJ Cryle et al.
AUSTRALIAN JOURNAL OF CHEMISTRY (2003)
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
Z Hojati et al.
CHEMISTRY & BIOLOGY (2002)
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases
D Schwarzer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria
JH Crosa et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2002)
Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase
JW Trauger et al.
NATURE (2000)
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
LC Du et al.
CHEMISTRY & BIOLOGY (2000)
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
GL Challis et al.
CHEMISTRY & BIOLOGY (2000)
Share Paper
