Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 56, Issue -, Pages 2-9Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2017.01.006
Keywords
Liver; Intestine; Bile acid; Homeostasis; Receptors
Funding
- Inserm
- CNRS
- Universite Clermont Auvergne
- Ministere de l'Enseignement Superieur et de la Recherche
- Ligue Contre le Cancer (Comite Puy de Dome)
- Nouveau Chercheur Auvergne [R12087CC]
- ANR Jeune Chercheur [1103]
- Plan Cancer -Cancer-Environnement InCa/Inserm [C14012CS]
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Primary bile acids are synthetized from cholesterol within the liver and then transformed by the bacteria in the intestine to secondary bile acids. In addition to their involvement in digestion and fat solubilization, bile acids also act as signaling molecules. Several receptors are sensors of bile acids. Among these receptors, this review focuses on the nuclear receptor FXRa and the G-protein-coupled receptor TGR5. This review briefly presents the potential links between bile acids and cancers that are discussed in more details in the other articles of this special issue of Molecular Aspects of Medicine focused on Bile acids, roles in integrative physiology and pathophysiology. (c) 2017 Elsevier Ltd. All rights reserved.
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