Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 58, Issue -, Pages 65-71Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2017.02.003
Keywords
Resolution of inflammation; Specialized pro-resolving mediators; Atherosclerosis
Funding
- NIH [HL119587, HL106173, GM095467]
- American Federation for Aging Research [A16034]
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The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recruitment of neutrophils, and promote the clearance of dead cells by macrophages. These mediators also enhance host-defense and couple resolution of inflammation to subsequent phases of tissue repair. Given that unresolved inflammation plays a causal role in the development of cardiovascular diseases, an understanding of these endogenous pro-resolving processes is critical for determining why cardiovascular inflammation does not resolve. Here, we discuss the receptor-dependent actions of resolvins and related pro-resolving mediators and highlight their emerging roles in the cardiovascular system. We propose that stimulating resolution could be a novel approach for treating chronic cardiovascular inflammation without promoting immunosuppression. (C) 2017 Published by Elsevier Ltd.
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