Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 459, Issue C, Pages 98-103Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.02.026
Keywords
Thyroid hormone (TH); Metamorphosis; Intestinal remodeling; Adult stem cell; Dedifferentiation; Stem cell niche
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Funding
- JSPS KAKENHI [15K07136]
- Grants-in-Aid for Scientific Research [15K07136] Funding Source: KAKEN
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In the amphibian intestine during metamorphosis, a small number of larval epithelial cells dedifferentiate into adult stem cells that newly form the adult epithelium analogous to the mammalian counterpart, while most of them undergo apoptosis. Because this larval-to-adult intestinal remodeling can be experimentally induced by thyroid hormone (TH) both in vivo and in vitro, TH response genes identified in the Xenopus intestine provide us valuable clues to investigating how adult stem cells and their niche are formed during postembryonic development. Their expression and functional analyses by using the culture and recent transgenic (Tg) techniques have shed light on key signaling pathways essential for intestinal stem cell development. The present review focuses on such recent findings and discusses the evolutionally conserved roles of TH in development or maintenance of the stem cells which are common to the terrestrial vertebrate intestines. (C) 2017 Elsevier B.V. All rights reserved.
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